This start of this season saw the return of the previous season’s panel. However, by the end of the show’s 2017-2018 run, Jedediah Bila had been replaced by political commentator Meghan McCain following Bila’s abrupt exit in September 2017. Similarly, both Sara Haines and Paula Faris announced that this season would be their last, with the former moving on to co-host the network’s new third hour of Good Morning America alongside Michael Strahan.
21 - 1Premiere Sep. 05, 2017- 21 - 2Sarah Huckabee Sanders, Mike Huckabee Sep. 06, 2017
- 21 - 104Guest Co-Hostess Catt Sadler/Michael B. Jordan Feb. 14, 2018
- 21 - 106Ronan Farrow and Hot Topics Feb. 16, 2018
- 21 - 196Alan Dershowitz Jul. 10, 2018
- 21 - 197DL Hughley Jul. 11, 2018
- 21 - 198Hot Topics and Ladies Get Lit Jul. 12, 2018
- 21 - 199John Quiñones Jul. 13, 2018
- 21 - 200Sherri Shepherd Jul. 16, 2018
- 21 - 20150 Cent Jul. 17, 2018
- 21 - 202Joel McHale & Daveed Diggs Jul. 18, 2018
- 21 - 203Jeanine Pirro Jul. 19, 2018
- 21 - 204Jennifer Garner Jul. 20, 2018
- 21 - 205Hot topics; items at affordable prices Jul. 23, 2018
- 21 - 206Henry Golding Jul. 24, 2018
- 21 - 207Van Jones, Bo Burnham, and Elsie Fisher Jul. 26, 2018
- 21 - 208Alan Alda Jul. 27, 2018
- 21 - 209Leslie Jones Jul. 30, 2018
- 21 - 210Amy Adams & Chris Messina Jul. 31, 2018
- 21 - 211Omari Hardwick Aug. 01, 2018
- 21 - 212Ewan McGregor Aug. 02, 2018
- 21 - 213Michael Avenatti & Ana Navarro Aug. 03, 2018